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Diflucan is used for treating and preventing certain yeast and fungal infections.

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Generic fluconazole vs diflucan ). On the basis of our data, we recommend that diflucan be used as first-line, once-daily therapy for AOM. However, we do not recommend the use of fluconazole for AOM due to its potential adverse effects and the for resistance. In addition, use of fluconazole as monotherapy for <$%OUTSIDE_LINK_0%$> PANDAS or AOM may be appropriate, with careful monitoring for the presence of resistance, especially given the significant frequency of resistance in PANDAS. Therefore, based on the best-evidence data, we suggest that clinicians not use monotherapy with cephalosporins and fluconazole but instead consider the use of one these antibiotics when used first-line, as recommended for cephalosporin allergy. The following are some caveats to the effectiveness and safety of fluconazole used to treat adults with PANDAS or AOM: The effectiveness of fluconazole for all patients is not known. Future study of AOM and PANDAS by conducting a randomized clinical trial is needed to examine fluconazole's potential effectiveness. The safety of fluconazole was recently noted during treatment of PANDAS patients with a second-line regimen.20 However, the safety of this study was not evaluated in this study because dose of fluconazole was chosen prior to the initiation of additional treatment in each patient. Future studies this setting should examine the efficacy and safety of fluconazole as monotherapy with other antibiotics, in combination additional AOM treatments, or both with additional AOM patients. Fluconazole exposure Fluconazole exposure for patients with PANDAS and AOM is not known due to the lack of efficacy studies for these agents and the fact that cephalosporin therapy typically must be started in patients younger than 8 years of age because its potential neurotoxicity. Therefore, it was not possible to compare the exposure for individuals treated with cephalosporins that of patients treated with fluconazole. Additionally, fluconazole who were treated with additional doses of drug store chains canada cephalosporins prior to monotherapy for PANDAS or AOM (with the exception of a patient who was first-line cephalosporin monotherapy) were excluded from the analysis of fluconazole exposure. In addition, it is also unknown whether fluconazole exposure for individuals with PANDAS or AOM depends on which agent is begun first. For reasons of availability, it was not possible to determine the actual duration of fluconazole exposure. Patients with PANDAS and AOM exposed to cephalosporins A small observational study by Stolz-Zifani et al21 concluded that first-line cephalosporins may be used to treat PANDAS patients with a cephalozole resistance profile. The current efficacy and safety of cephalosporins in treating PANDAS and AOM appear.

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